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Erythema multiforme (em) is a letter, self limited, and sometimes recurring skin condition that is considered to be a type iv hypersensitivity reaction associated with certain infections, medications, and other various triggers. [1]
Erythema multiforme may be present within a wide spectrum of severity.Erythema multiforme minor represents a localized eruption of the skin with minimal or no mucosal involvement. the papules evolve into pathognomonic target or iris lesions that appear within a 72 hour period and begin on the extremities (see the following image). Lesions remain in a fixed location for at least 7 days and then begin to heal.an arcuate appearance may be present (see the second image below). Precipitating factors include simplex herpes virus (hsv), epstein - barr virus (EBV), and histoplasmosis. because this condition may be related to a persistent antigenic stimulus, recurrence is the rule rather than the exception, with most affected individuals experiencing 1 - 2 recurrences per year.
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