В исследовании были использованы кр

В исследовании были использованы крысы аутбредного разведения Sprague-Dawley (CD) в возрасте 3,5 недель (80 животных) и кролики Шиншилла в возрасте 5-6 недель (64 животных). Препарат вводился зондом в желудок крысам в течение 25-ти дней в дозах 50, 600 и 1200 мг/кг, кролика в течение 30-ти дней в дозах 25, 200 и 400 мг/кг. У животных регистрировали внешние проявления отклонений в состоянии здоровья, смертность, прирост массы тела, потребление корма. После окончания периода введения животных подвергали эвтаназии и проводили некропсию, органы взвешивали, фиксировали, делали гистологические срезы для микроскопического исследования, определяли показатели гематологии и биохимии сыворотки крови. Половину животных (крысы и кролики), получавших препарат в максимальной дозе, оставляли на 14 дней для периода восстановления и регистрации отсроченных эффектов.

Результаты (английский) 1:

The study used rats Sprague-Dawley breeding autbrednogo (CD) at the age of 3.5 weeks (80 animals) and Chinchilla rabbits aged 5-6 weeks (64). The drug was administered to rats in a stomach probe within 25 days at doses of 50, 600 and 1200 mg/kg rabbit during 30 days at doses of 25, 200 and 400 mg/kg. Animals have registered the outward manifestations of deviations in health, mortality, body weight gain, feed intake. After the end of the period of introduction of animals subjected to euthanasia and nekropsiû, authorities weighed, recorded, did histological sections for microscopic examination, determined indicators of Hematology and serum biochemistry. Half of the animals (rats and rabbits), receiving the drug at the highest dose, left for 14 days for the recovery period and the registration of deferred effects.

Результаты (английский) 2:

The study used a rat breeding outbred Sprague-Dawley (CD) at the age of 3.5 weeks (80 animals) and Chinchilla rabbits aged 5-6 weeks (64 animals). The drug was administered into the stomach probe to rats for 25 days at doses of 50, 600 and 1200 mg / kg in the rabbit for 30 days at doses of 25, 200 and 400 mg / kg. The animals were recorded symptoms deviations in health, mortality, body weight gain, feed intake. After the end of the administration period, the animals were euthanized and a necropsy was performed, organs were weighed, fixed, made histological sections for microscopic examination, determined the performance of hematology and biochemistry blood serum. Half of the animals (rats and rabbits), received the highest dose was left for 14 days recovery period and registration delayed effects.

Результаты (английский) 3:

In the study were used rat breeding аутбредного Sprаgue-Dаwley (CD) at the age 3.5 weeks (80 animals) and rabbits is chinchilla at the age of 5 or 6 weeks (64 animals).The Medication entered probe in the stomach in rats during the 25-days in doses 50, 600, and 1200 mg/kg, rabbit in 30-days in doses 25, 200, and 400 mg/kg). In animals registered external manifestations of event in the state of health,Mortality rates, increase in body weight, feed consumption. After the end of the period of the animals have been subjected to legalised euthanasia and conducted некропсию, organs weighed, observing,Did immunohistochemical investigations slices for microscopic study, to define indicators haematology and blood biochemistry serum. Half of animals (rats and rabbits), receiving the medication in maximum dose information,Leave for 14 days for recovery period and registration delayed effects.