Влияние Мексидола на постнатальное

Влияние Мексидола на постнатальное развитие потомства. Опыты поставлены на крысах, которым вводили мексидол внутрижелудочно с помощью желудочного зонда в дозе 250 мг/кг в течение всей беременности, в сравнении с контрольной группой. В результате исследования было установлено, что на 5 и 15 –й день жизни крысята обоих полов, подвергнутые антенатальному воздействию препарата мексидол, весили несколько больше контрольных к 30 дню жизни, разница сглаживалась, и подопытные крысята весили практически столько же, что и контрольные. По срокам физического развития опытные крысята несколько опережали контрольных. При изучении поведения одномесячных крысят в «открытом поле» не было обнаружено, каких либо различий между крысятами обеих групп по показателям вертикальной и горизонтальной двигательной активности, выраженности исследовательской и эмоциональной реакции. Для оценки способности 2-х месячных крысят избегать стрессовую ситуацию использовали модифицированную методику Хендерсона, в результате по всем изучаемым показателям поведение контрольных и опытных животных в условиях стрессорной ситуации не различалось.

Результаты (английский) 1:

Influence mexidol on the postnatal development of progeny. The experiments placed on rats which were injected mexidol into a stomach using gastric probe at a dose of 250 mg/kg during pregnancy, as compared with the control group. The study found that on 5 and 15-th day of the life of the pups of both sexes, subjected to antenatal′nomu effects of the drug, weighed slightly more mexidol control to 30 day of life, the difference sglaživalas′ and experimental pups weighed virtually the same as that of the control. In terms of physical development experienced several pups ahead of control. When studying the behavior of rats in one-month "open field" did not find any differences between the two groups on indicators krysâtami vertical and horizontal mobility, symptoms, research and emotional reactions. To evaluate the ability of 2-x monthly rats avoid needn't have used a modified technique of Henderson, as a result, for all indicators of behavior control and experienced animals in stressornoj conditions situation differed.

Результаты (английский) 2:

Influence Mexidol on postnatal development of offspring. The experiments were conducted on rats administered meksidol intragastrically by gavage at a dose of 250 mg / kg during pregnancy, compared with the control group. The study found that 5 and 15 th day of life of rats of both sexes subjected to the effects of antenatal preparation mexidol weighed a bit more control by the 30th day of life, the difference is smoothed, and the experimental rats weighed almost as much as the control. In terms of physical development of experimental rats a few ahead of control. In the study of the behavior of one-month rats in the "open field" was not found any differences between the pups from both groups in terms of vertical and horizontal motor activity, research and expression of emotional reactions. To assess the ability of a 2-month rats to avoid stressful situations using a modified method of Henderson, as a result of all the indicators studied the behavior of the control and experimental animals in terms of stress of the situation was not different.

Результаты (английский) 3:

Impact Мексидола on development-progeny. Experiments put on the rats, which had imposed мексидол внутрижелудочно using the pancreas ferments probe in the dose 250 mg/kg throughout the pregnancy,In comparison with the control group. As a result of the study it was found that, at the 5 and 15-day life of a captain at twenty - both sexes, auditee антенатальному effects drug мексидол,Weigh a few more control to the 30 day of life, the difference сглаживалась, a captain at twenty - and potentially patentable information weigh almost as much as that, and reference.The time-bound physical development experienced a captain at twenty - a few exceeded control. In examining the conduct of month крысят in the "open field" was not detected,Any differences between крысятами both groups of indicators vertical and horizontal motion, gynecologic research and emotional reaction.To assess the ability of the 2-monthly крысят to avoid stresses situation have used a modified procedure Henderson,As a result, all the repliers indicators behavior control and experienced animals in conditions стрессорнои situations not adhere.