Проведена сравнительная оценка двух

Проведена сравнительная оценка двух выборок по критерию степени гетероплазмии девяти мутаций митохондриального генома, которые ассоциированы с факторами риска атеросклероза, главным образом, с ишемической болезнью сердца (ИБС). Подтверждена высокодостоверная ассоциация мутаций C3256T (ген MT-TL1), G12315A (ген MT-TL2), G13513A (ген MT-ND5) и G15059A (ген MT-CYB) с возникновением риска сердечно-сосудистых заболеваний методом ПЦР-РВ. Рассчитан генетический риск атеросклеротических поражений сосудов на основании анализа совокупностей мутационной нагрузки митохондриального генома по данным мутациям.

Результаты (английский) 1:

The comparative estimation of two samples on the criterion of the degree of geteroplazmii mutations of mitochondrial genome of nine that are associated with risk factors for atherosclerosis, mainly with coronary heart disease (CHD). Confirmed by vysokodostovernaâ Association of C3256T mutations (MT-TL1 gene), G12315A (MT-TL2 gene), G13513A (MT-ND5 gene) and G15059A (MT-CYB gene) with the emergence of risk of cardiovascular diseases by PCR-PB. Calculated genetic risk of atherosclerotic lesions of vessels based on the analysis of aggregates of mutational load of mitochondrial genome according to mutations.

Результаты (английский) 2:

A comparative evaluation of the two samples on the criterion of the degree of heteroplasmy nine mutations of the mitochondrial genome that are associated with risk factors for atherosclerosis, mainly with coronary heart disease (CHD). Very close association confirmed mutation C3256T (gene MT-TL1), G12315A (gene MT-TL2), G13513A (gene MT-ND5) and G15059A (gene MT-CYB) with the emergence of the risk of cardiovascular disease by RT-PCR. Designed genetic risk of atherosclerotic vascular lesions based on the analysis of sets of mutational load according to the mitochondrial genome mutations.

Результаты (английский) 3:

a comparative evaluation of the two samples on the basis of the degree of гетероплазмии nine mutations митохондриального genome, which are associated with risk factors for atherosclerosis, mainlywith coronary heart disease (cd). confirmed высокодостоверная association (gene mutations C3256T mt - TL1), G12315A (mt - TL2 gene (gene), G13513A mt - ND5) and G15059A (gene mt - CYB) due to the risk of cardiovascular disease by pcr - 2000.calculated the genetic risk атеросклеротических vascular lesions on the basis of analysis of a combination of mutation load митохондриального genome according to the mutation.