Для оценки эффективности терапии на

Для оценки эффективности терапии на 7-е сутки после оживления проводили гистологическое исследование гиппокампа у интактной группы животных и реанимированных крыс разных групп (по 3-4 крысы в каждой группе). С помощью морфометрического анализа оценивали плотность и состав нейрональных популяций пирамидных клеток СА1 и СА4 гиппокампа. Особенности поведения животных исследовали в ряде тестов в течение 4 мес. В постреанимационном периоде после однократного введения мексидола отмечалось более быстрое восстановление роговичного рефлекса и уменьшение неврологического дефицита на 1-е сутки по сравнению с реанимированными животными с введением плацебо. На 5-е сутки в опытной группе с мексидолом отмечалось достоверно большее количество животных с исчезновением НД.

Результаты (английский) 1:

To evaluate the effectiveness of therapy on the 7th day after resuscitation conducted histological study of the hippocampus at the intact animal group and resuscitated rats of different groups (3-4 rats in each group). Using a morphometric analysis assessed the density and composition of neuronal populations of pyramidal cells in the Ca1 and ca4 hippocampal. Animal behaviors were studied in a number of tests during 4 months. In the postresuscitative period after a single injection of mexidol noted faster recovery of the corneal reflex and reduction of neurologic deficiency on day 1 compared to reanimirovannymi animals with the introduction of the placebo. On the 5th day in the experimental group with meksidolom noted a greater number of animals reliably with the disappearance of the LP.

Результаты (английский) 2:

To evaluate the effectiveness of treatment on the 7th day after resuscitation examined histologically hippocampal intact group of animals and resuscitated rats of different groups (3-4 rats in each group). By morphometric analysis of the composition were evaluated and the density of neuronal populations pyramidal cells of CA1 and CA4 of the hippocampus. Features of animal behavior was studied in a number of tests for 4 months. Postresuscitation after a single administration mexidol noted faster recovery of corneal reflex and a decrease of neurological deficit on day 1 compared to animals resuscitated with the introduction of a placebo. On the 5th day in the experimental group had significantly greater meksidolom number of animals with the disappearance of the LP.

Результаты (английский) 3:

For evaluation of the effectiveness treatment on 7-e per day after recovery % study conducted in hippocampal интактнои group animals and реанимированных rats different groups (on 3-4 rats in each group).Using the морфометрического analysis evaluated the density and the composition of the two populations of pyramid cells CA1 and Ca4 hippocampal region. Features of behavior of animals explored in some tests for 4 months.In the post-ICU care after a single introduction мексидола noted a more rapid recovery роговичного reflex and decrease blood coagulability deficit at 1-e per day, compared with реанимированнымиWith the introduction of the placebo.The 5-e per day in experimental group with мексидолом noted reliably increasing the number of animals with the disappearance OD.