гемостатических, атравматических, а

гемостатических, атравматических, антимикробных и ранозаживляющих повязок, дренажей и т.д. Ряд работ посвящен применению акриловых ГГ для изготовления контактных линз и искусственных органов. Так, на основе сополимеров АК, НИПАА и полидиметилсилоксана сделана попытка создания искусственной поджелудочной железы, т.е. устройства, выделяющего инсулин в ответ на изменение концентрации глюкозы [Uchida T., Toida Y., Sakakibara S., Tanaka H. Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers//Chem. Pharm. Bull.  2001.  V.49, №10.  P. 1261  1266]. Для изготовления изделий, контактирующих с тканями живого организма, напримерэндопротезов, наиболее широкое распространение получили гидрогели на основе ГЭМА [Валуев И.Л., Кудряшов В.К., Обыденнова И.В. Исследование свойств гидрогелей на основе сополимеров 2-гидроксиэтилметакрилата//Вестн. Моск. ун-та. 2003. Сер.2. Химия. Т.44, №2. С. 149  152]. Сополимеры винилового спирта и АК используются для создания так называемых искусственных мускул, используемых в различных приборах в качестве пальцеподобных зажимных устройств, мягких микроманипуляторов и т.д. Акриловые СВА используются для выделения и очистки биологически активных веществ и иммобилизации биокатализаторов, в биосенсорах, для моделирования процессов регуляции в живой клетке, связанных с фазовыми переходами в мембранах, а также для создания лекарственных препаратов с пролонгированным действием [Pekel N., Sahiner N., Güven O. Hydrogels for the removal of heavy metal ions from aqueous systems//Rad. Phys. Chem.  2000.  V.59.  P. 485 – 489]. В основном, при создании композиций, используемых для постепенного выделения лекарства в организме человека, например, никотина, парацетамола, этофилина, теофилина и т.д, применяются рН- или термочувствительные сшитые полимеры, обладающие обратимым фазовым переходом. Такие макро-, микро- и наноскопические гидрогелевые трехмерные сетки характеризуются критической температурой растворения или критическим значением рН. Помимо хорошо известного поли(N-изопропилакриламида), в качестве полимерной основы синтеза композиций медицинского назначения используются: поли(N,N'-диэтилакриламид), поли(N-этил,N-метилакриламид) и поли(N-пирролидинакриламид) и т.д. [Галаев И.Ю. «Умные» полимеры в биотехнологии и медицине//Успехи химии. – 1995. – Т.64, №5. – С.505  524.]. Применение ГГ на основе АК и ее сополимеров в биотехнологии и медицине связано, прежде всего, с их мультифункциональной природой, уникальными свойствами и хорошей биосовместимостью [Pekel N., Sahiner N., Güven O. Hydrogels for the removal of heavy metal ions from aqueous systems // Rad. Phys. Chem.  2000.  V.59.  P. 485 – 489.; Lopatin V. V., Askadskii A. A., Peregudov A. S. Structure and Properties of Polyacrylamide Gels for Medical Applications// Polym. Bull. – 2004. – V. 46A, № 12. – P.425  431].

Результаты (английский) 1:

Hemostatic, antimicrobial, atravmatičeskih and ranozaživlâûŝih casts, drainage and so on a series of works devoted to the application of acrylic GG for the manufacture of contact lenses and artificial organs. So, on the basis of copolymers of AK, NIPAA and polydimethylsiloxane attempted to create an artificial pancreas, i.e. devices, makes insulin in response to glucose concentration [Uchida t., Toida Y, Sakakibara S, Tanaka H. Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers//Chem. Pharm. Bull. 2001  . V. 49, no. 10. P. 1261   1266]. For the manufacture of products that come into contact with the tissues of a living organism, naprimerèndoprotezov, the most widespread hydrogels on the basis HER [Valuev I.l., Kudryashov v.k., Obydennova I.v. Study properties of hydrogels based on copolymers of 2-hydroxyethyl methacrylate//Vestn. Mosk. UN-Ty. 2003. Ser. 2. Chemistry. Vol. 44, no. 2. C. 149  152]. Vinyl alcohol copolymers and used to create a so-called artificial muscle is used in various devices as pal′cepodobnyh clamping devices, soft micromanipulators etc Acrylic SVA are used for separation and purification of bioactive substances and immobilization of biocatalysts, biosensors, for modeling regulation in living cell associated with phase transitionsin the membranes, as well as for the creation of medicinal preparations with prolonged action [Pekel n. Sahiner, n., o. Güven Hydrogels for the removal of heavy metal ions from aqueous systems//Rad Phys. Chem. 2000  . V. 59.  p. 485-489]. Basically, when you create compositions used for progressive allocation of drugs in the human body, for example, nicotine, paracetamol, ètofilina, teofilina, etc., apply pH or temperature-sensitive polymers possessing stitched reversible phase transition. Such macro-, micro-and nanoskopičeskie Hydrogel 3D meshes is characterized by critical temperature dissolution or critical pH value. In addition to the well-known poly (N-izopropilakrilamida), as a synthesis of the polymer base compositions of medical supplies used: poly (N, n '-diètilakrilamid), poly (N-ethyl N-metilakrilamid) and poly (N-pirrolidinakrilamid), etc. [Galaev I.y. smart polymers in biotechnology and medicine//Advances chemistry.-1995., i.e. 64, no. 5-c. 505 524 .]. Application GG based on AK and its copolymers in biotechnology and medicine is primarily with their multifunctional nature, unique properties and good biocompatibility [Pekel n. Sahiner, n., o. Güven Hydrogels for the removal of heavy metal ions from aqueous systems//Rad Phys. Chem. 2000  . V. 59.  p. 485-489; Lopatin v. v., Askadskii a. a., a. Peregudov s. Structure and Properties of Polyacrylamide Gels for Medical Applications//Polym. Bull. -2004. -V. 46A, no. 12. -P. 425  431].

Результаты (английский) 2:

hemostatic, atraumatic, antimicrobial and wound healing dressings, drains, etc. A number of works devoted to the application for the production of acrylic SG contact lenses and artificial organs. So, based on copolymers AK, Nipah and polydimethylsiloxane attempt to create an artificial pancreas, ie, device secretes insulin in response to glucose concentrations [Uchida T., Toida Y., Sakakibara S., Tanaka H. Preparation and characterization of insulin-loaded acrylic hydrogels containing absorption enhancers // Chem. Pharm. Bull.  2001.  V.49, №10.  P. 1261  1266]. For the manufacture of products that come into contact with the tissues of a living organism, naprimerendoprotezov most widespread hydrogels based on HEMA [Valuev IL, VK Kudryashov, Obydennova IV Studying the properties of hydrogels based on copolymers of 2-hydroxyethyl methacrylate // Vestn. Mosk. Univ. 2003 Ser.2. Chemistry. T.44, №2.  149 S. 152]. Copolymers of vinyl alcohol and AK used for the creation of so-called artificial muscle used in various devices as a finger-gripping devices, soft micromanipulators etc. Acrylic NEA used for isolation and purification of biologically active substances and biocatalysts immobilization in biosensors, for the simulation of regulation in living cells associated with phase transitions in membranes, as well as to create drugs with prolonged action [Pekel N., Sahiner N., Güven O. Hydrogels for the removal of heavy metal ions from aqueous systems // Rad. Phys. Chem.  2000.  V.59.  P. 485 - 489]. In general, when a composition used for the gradual release of the drug in the human body, for example, nicotine, acetaminophen, etofilina, theophylline, etc., apply pH- or thermosensitive crosslinked polymers having a reversible phase transition. Such macro, micro and nanoscopic hydrogel three-dimensional networks are characterized by a critical temperature or critical dissolution pH. In addition to the well known poly (N-isopropylacrylamide) as the backbone polymer compositions synthesis medical supplies used: poly (N, N'-diethylacrylamide), poly (N-ethyl, N-methylacrylamide), and poly (N-pirrolidinakrilamid) and m. d. [IJ Galaev 'Smart' polymers in biotechnology and medicine // Russian Chemical. - 1995 - T.64, №5. - S.505  524.]. Application of HS-based AK and its copolymers in biotechnology and medicine primarily connected with their multi-functional nature, unique features and good biocompatibility [Pekel N., Sahiner N., Güven O. Hydrogels for the removal of heavy metal ions from aqueous systems // Rad. Phys. Chem.  2000.  V.59.  P. 485 - 489 .; Lopatin VV, Askadskii AA, Peregudov AS Structure and Properties of Polyacrylamide Gels for Medical Applications // Polym. Bull. - 2004. - V. 46A, № 12. - P.425  431].

Результаты (английский) 3:

гемостатических, атравматических, антимикробных and ранозаживляющих дренажей bandages, and so on. a number of works dedicated to the use of acrylic and for the manufacture of contact lenses and artificial organs. so,on the basis of сополимеров ak, нипаа and полидиметилсилоксана attempted to create an artificial pancreas, i.e. the device выделяющего insulin in response to changes in glucose concentration (Uchida t., Toida y., Sakakibara s.tanaka h. preparation and characterization of insulin loaded acrylic hydrogels containing / enhancers / / chem. Pharm. bull. the photos of 2001. the photos V.49, 10. photos p. 1261 photos 1266]. for the manufacture of products, contact with the tissues of a living organism напримерэндопротезов,the most widespread гидрогели based on гэма [valuev и.л., в.к. kudryashov, обыденнова и.в. study on the properties of гидрогелей based on сополимеров 2 - гидроксиэтилметакрилата / / вестн. head. mi ta. 2003.сер.2. chemistry. т.44, 2. with the. 149 photos 152]. copolymer винилового alcohol and ak are used to create so-called artificial muscles used in various devices as пальцеподобных зажимных devicesthe soft микроманипуляторов and so on. acrylic eas are used for allocation and purification of biologically active substances and the immobilization of biocatalysts in биосенсорах,to simulate the processes of regulation in living cells of фазовыми gradients in membranes, working its way as well as to develop drugs with пролонгированным act [Pekel n., Sahiner n., Güven oh.Hydrogels for the removal of heavy metal from aqueous ions systems / / rad. Phys. chem. the photos of 2000. the photos V.59. photos p. 485 - 489). most of the tracks used for the progressive provision of drugs in the human body, for example, nicotine, paracetamolэтофилина, теофилина etc., applied ph or heat sown polymers with reversible phase transition. such macro.micro - and наноскопические hydro gel three-dimensional grid are critical dissolution temperature or the critical ph value. in addition to the well known poly (n - изопропилакриламида)as a basis for synthesis of polymer compositions for medical use are used: poly (n, n '- диэтилакриламид), poly (n - ethyl, n - метилакриламид) and poly (n - пирролидинакриламид) and so on. [галаев и.ю."smart polymers in biotechnology and medicine / / achievements of chemistry. - 1995. - т.64, 5. - с.505 photos 524]. application and on the basis of ak and its сополимеров in biotechnology and medicine related, first of all, with their мультифункциональной naturethe unique properties and good биосовместимостью [Pekel n., Sahiner n., Güven oh. Hydrogels for the removal of heavy metal from aqueous ions systems / / rad. Phys. chem. the photos of 2000. the photos V.59. photos p. 485 - 489.; Lopatin v. v., Askadskii a. a., Peregudov a. s. structure and properties of Polyacrylamide Gels for medical applications / / Polym. bull. - 2004.is v. 46A, no. 12. - P.425 photos 431].