Метаболит II (2,6-диметил-3-оксипир

Метаболит II (2,6-диметил-3-оксипиридин), наряду с неизмененным веществом, также обладает высокой фармакологической активностью. Выявленные корреляции между динамикой содержания Мексидола в плазме и мозге крыс, его анксиолитическим действием, а также изменениями электрофизиологических показателей, указывают на важную роль фармакокинетических закономерностей Мексидола в проявлении его различных видов фармакологической активности.

Результаты (английский) 1:

Metabolite II (2.6-dimethyl-3-oksipiridin), along with unchanged substance also has high pharmacological activity. Identified a correlation between dynamics of Mexidol content in plasma and brain of rats, his anxiolytic action, as well as changes of electrophysiological indices indicate the important role of the pharmacokinetic of Mexidol regularities of its various types of pharmacological activity.

Результаты (английский) 2:

Metabolite II (2,6-dimethyl-3-hydroxypyridin), along with the unmodified substance also has high pharmacological activity. The correlation between the dynamics of content Mexidol in the plasma and brain of rats, its anxiolytic effects, as well as changes in the electrophysiological indicators point to an important role of pharmacokinetic Mexidol regularities in the manifestation of its various types of pharmacological activity.

Результаты (английский) 3:

Metabolite II (2.6 -диметил-3-оксипиридин), together with the unchanged substance, also has a high pharmacological activity. The correlation between the dynamics of Мексидола in plasma and brain in rats,His анксиолитическим action, as well as revised ep indicators,Indicate the important role agents administered (pharmacokinetics patterns Мексидола in manifestations of its various types of pharmacological activity.